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14 A 2017 meta-analysis of 52 randomized, controlled trials that evaluated DPP-4 inhibitors' effects on beta-cell function found that, in monotherapy studies, all agents except linagliptin resulted in improvements in cell function

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Moreover, deletion of Bach1 with an adenoviral vector encoding Bach1 shRNA was sufficient to promote HO-1 expression in cardiomyocytes (Supplemental Fig